Receptor of the Estrogen and cell Destiny
Estradiol (E2) controls a variety of physiological processes, including growth, development, metabolism, homeostasis and reproduction. E2 is also intimately associated with several human pathologies, for instance breast cancers, osteoporosis, coronary or Alzheimer's diseases, and exerts both desirable and harmful effects on these pathological processes. Comprehension of the cellular and molecular mechanisms underlining these pleiotropic effects of estradiol is the main goal of our team. Notably, we are studying how E2 and its receptors (ERs) control cell fate, as proliferation, differentiation and apoptosis.
Themes currently studied are:
Themes currently studied are:
- Estrogen signalling in breast cancers: cross-talk between estrogen receptor and the orphan receptor COUP-TFI.
- Estrogen receptor and cellular protection: implication in the cardiovascular and the central nervous system.
- Tissue-specific activity of the transactivation functions of the estrogen receptor.
- Finally, data and tools from fondamental studies are used to screen endocrine disrupters and to define criteria to select SERM "Selective Estrogen Receptor Modulators".