Publications
2007
Nettles KW, Gil G, Nowak J, Métivier R, Sharma VB, Greene GL. CBP is a dosage dependent regulator of NFκB suppression by the estrogen receptor. Mol Endocrinol [Epub ahead of print].
Feige JN, Gelman L, Rossi D, Zoete V, Métivier R, Tudor C, Anghel SI, Grosdidier A, Lathion C, Engelborghs Y, Michielin O, Wahli W, Desvergne B. The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J Biol Chem. 282:19152-19166.
Gallais R, Demay F, Barath P, Finot L, Jurkowska R, Le Guevel R, Gay F, Jeltsch A, Métivier R, Salbert G. Deoxyribonucleic Acid Methyl Transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene Activation. Mol Endocrinol. 21:2085-2098.
- Eeckhoute J, Keeton EK, Lupien M, Krum SA, Carroll JS, Brown M. Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer. Cancer Res. 67:6477-6483.
- Demay F, Bilican B, Rodriguez M, Carreira S, Pontecorvi M, Ling Y, Goding CR. T-box factors: targeting to chromatin and interaction with the histone H3 N-terminal tail. Pigment Cell Res 20:279-287.
Le Dily F, Métivier R, Gueguen MM, Le Péron C, Flouriot G, Tas P, Pakdel F. COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells. Breast Cancer Res Treat. [Epub ahead of print].
2006
- Métivier R, Reid G, Gannon F. Transcription in four dimensions: nuclear receptor-directed initiation of gene expression. EMBO Rep. 7:161-167. Review.
- Eeckhoute J, Briche I, Kurowska M, Formstecher P, Laine B. Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1. J Mol Biol. 364:567-581.
- Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet. 38:1289-1297.
- Eeckhoute J, Carroll JS, Geistlinger TR, Torres-Arzayus MI, Brown M. A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer. Genes Dev. 20:2513-2526
- Lemaire V, Lee CF, Lei J, Métivier R, Glass L. Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation. Phys Rev Lett. 96:198102.
2005
Penot G, Le Péron C, Mérot Y, Grimaud-Fanouillere E, Ferriere F, Boujrad N, Kah O, Saligaut C, Ducouret B, Métivier R, Flouriot G. The human Estrogen Receptor alpha isoform hERα46 antagonizes the proliferative influence of hERα66 in MCF7 breast cancer cells. Endocrinology. 146:5474-5484.
Valley CC, Métivier R, Solodin NM, Fowler AM, Mashek MT, Hill L, Alarid ET. Differential regulation of estrogen-inducible proteolysis and transcription by estrogen receptor-α N-terminus. Mol. Cell. Biol. 25:5417-5428.
Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell. 122:33-43.
Reid G, Métivier R, Lin C-Y, Denger S, Ibberson D, Ivacevic T, Brand H, Benes V, Liu ET, Gannon F. Multiple mechanisms induce transcriptional silencing of a subset of genes, including estrogen receptor α, in response to deacetylase inhibition by valproic acid and trichostatinA. Oncogene. 24:4894-4907.
2004
Métivier R. Activation of gene transcription. Med Sci Paris. 20:391-393. Review.
Bourdeau V, Deschênes J, Métivier R, Nagai Y, Nguyen D, Bretschneider N, Gannon F, White JH, Mader S. Genome-wide identification of high affinity estrogen response elements in human and mouse. Mol Endocrinol. 18:1411-1427.
Merot Y, Métivier R, Penot G, Manu D, Saligaut C, Gannon F, Pakdel F, Kah O, Flouriot G. The relative contribution that both AF-1 and AF-2 transactivation functions exert on estrogen receptor alpha (ERα) transcriptional activity is cell differentiation stage dependent. J Biol Chem. 279:26184-26191.
- Métivier R, Penot G, Carmouche RP, Hübner MR, Reid G, Denger S, Manu D, Brand H, Kos M, Benes V, Gannon F. Transcriptional complexes engaged by apo-estrogen receptor-α isoforms have divergent outcomes. EMBO J. 23:3653-3666.
- Eeckhoute J, Formstecher P, Laine B. Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription. Nucleic Acids Res. 32:2586-2593.
Le Goff P, Le Drean Y, Le Peron C, Le Jossic-Corcos C, Ainouche A, Michel D. Intracellular trafficking of heat shock factor 2. Exp Cell Res. 294:480-93.
Le Page Y, Demay F, Salbert G. A neural-specific splicing event generates an active form of the Wiskott-Aldrich syndrome protein. EMBO Rep. 5:895-900
2003
- Reid G, Hübner MR, Métivier R, Brand H, Denger S, Manu D, Beaudouin J, Ellenberg J, Gannon F. Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signalling. Mol Cell. 11:695-707.
- Eeckhoute J, Oxombre B, Formstecher P, Lefebvre P, Laine B. Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4alpha dimerisation and transcriptional activity. Nucleic Acids Res. 31:6640-6650.
- Métivier R, Penot G, Hübner MR, Reid G, Brand H, Kos M, Gannon F. Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell. 115:751-763.
- Eeckhoute J, Moerman E, Bouckenooghe T, Lukoviak B, Pattou F, Formstecher P, Kerr-Conte J, Vandewalle B, Laine B. Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms. Endocrinology. 144:1686-1694.
2002
Dian C, Eshaghi S, Urbig T, McSweeney S, Heijbel A, Salbert G, Birse D. Strategies for the purification and on-column cleavage of glutathione-S-transferase fusion target proteins. J Chromatogr B Analyt Technol Biomed Life Sci. 769:133-144.
Gay F, Barath P, Desbois-Le Péron C, Métivier R, Le Guével R, Birse D, Salbert G. Multiple phosphorylation events control COUP-TFI orphan receptor activity. Mol Endocrinol. 16:1332-1351.
- Métivier R, Gay F, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F. Formation of an hERα-COUP-TFI complex enhances hERα AF-1 through Ser118 phosphorylation by MAPK. EMBO J. 21:3443-3453.
- Oxombre B, Moerman E, Eeckhoute J, Formstecher P, Laine B. Mutations in hepatocyte nuclear factor 4alpha (HNF4alpha) gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells. J Mol Med. 80:423-430.
- Clerc P, Saillan-Barreau C, Desbois C, Pradayrol L, Fourmy D, Dufresne M. Transgenic mice expressing cholecystokinin 2 receptors in the pancreas. Pharmacol Toxicol. 91:321-326. Review.
Métivier R, Stark A, Flouriot G, Hübner MR, Brand H, Penot G, Manu D, Denger S, Reid G, Koš M, Russell RB, Kah O, Pakdel F, Gannon F. A dynamic structural model for estrogen receptor-alpha activation by ligands emphasizing the role of interactions between distant A and E domains. Mol Cell. 10:1019-1032.
2001
Sourisseau T, Desbois C, Debure L, Bowtell DD, Cato AC, Schneikert J, Moyse E, Michel D. Alteration of the stability of Bag-1 protein in the control of olfactory neuronal apoptosis. J Cell Sci. 114:1409-1416.
- Métivier R, Penot G, Flouriot G, Pakdel F. Synergism between ERα transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 α-helical core and for a direct interaction between the N- and C-terminal domains. Mol Endocrinol. 15:1953-1970.
- Eeckhoute J, Formstecher P, Laine B. Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator. Mol Endocrinol.15:1200-1210.
Demay F, De Monti M, Tiffoche C, Vaillant C, Thieulant ML. Steroid-independent activation of ER by GnRH in gonadotrope pituitary cells. Endocrinology. 142:3340-3347.
Madigou T, Le Goff P, Salbert G, Cravedi JP, Segner H, Pakdel F, Valotaire Y. Effects of nonylphenol on estrogen receptor conformation, transcriptional activity and sexual reversion in rainbow trout (Oncorhynchus mykiss). Aquat Toxicol. 53:173-186.
2000
Pakdel F, Métivier R, Flouriot G, Valotaire Y. Two estrogen receptor (ER) isoforms with different estrogen-dependencies are generated from the trout ER gene. Endocrinology. 141:571-580.
Gay F, Anglade I, Gong Z, Salbert G. The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Mol Endocrinol. 14:1627-1648.
Métivier R, Le Dréan Y, Salbert G, Pakdel F. Interplay between liganded and orphan nuclear receptors controls reproductive pathways. Biochem Cell Biol. 78:345-358. Review.
- Flouriot G, Brand H, Denger S, Métivier R, Kos M, Reid G, Sonntag-Buck V, Gannon F. Identification of a new isoform of the human estrogen receptor-alpha (hER-α) that is encoded by distinct transcripts and that is able to repress hER-α activation function 1. EMBO J. 19:4688-4700.
- Laine B, Eeckhoute J, Suaud L, Briche I, Furuta H, Bell GI, Formstecher P. Functional properties of the R154X HNF-4alpha protein generated by a mutation associated with maturity-onset diabetes of the young, type 1. FEBS Lett. 479:41-45.
Métivier R, Petit FG, Valotaire Y, Pakdel F. Function of N-terminal transactivation domain of estrogen receptor requires a potential α-helical structure and is negatively regulated by the A domain. Mol Endocrinol. 14:1849-1871.
Adam F, Sourisseau T, Métivier R, Le Page Y, Desbois C, Michel D, Salbert G. COUP-TFI regulates cell migration and axogenesis in differentiating P19 embryonal carcinoma cells. Mol Endocrinol. 14:1918-1933.
Le Guevel R, Petit F, Le Goff P, Métivier R, Valotaire Y, Pakdel F. Cadmium: an inhibitor of estrogen receptor activity. Biol Reprod. 63:259-266.
90's
Petit FG, Métivier R, Valotaire Y, Pakdel F. Synergism between a half-site and an imperfect estrogen-responsive element, and cooperation with COUP-TFI are required for estrogen receptor (ER) to achieve a maximal estrogen-stimulation of rainbow trout ER gene. Eur J Biochem 1999. 259:385-395.
Sourisseau T, Le Drean Y, Salbert G, Flamant F, Michel D. Eukaryotic conditional expression system. Biotechniques 1999. 27:106-110.
Desbois C, Huerou-Luron IL, Dufresne M, Estival A, Clerc P, Rome V, Clemente F, Guilloteau P, Fourmy D. The CCKB/gastrin receptor is coupled to the regulation of enzyme secretion, protein synthesis and p70 S6 kinase activity in acinar cells from ElasCCKB transgenic mice. Eur J Biochem 1999. 266:1003-1010.
Le Dréan G, Le Huerou-Luron I, Gestin M, Desbois C, Romé V, Bernard C, Dufresne M, Moroder L, Gully D, Chayvialle JA, Fourmy D, Guilloteau P. Exogenous CCK and gastrin stimulate pancreatic exocrine secretion via CCK-A but also via CCK-B/gastrin receptors in the calf. Pflugers Arch 1999. 438:86-93.
Ciana P, Braliou GG, Demay FG, von Lindern M, Barettino D, Beug H, Stunnenberg HG. Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo. EMBO J 1998. 17:7382-7394.
Desbois C, Clerc P, Le Huerou-Luron I, Le Dréan G, Gestin M, Dufresne M, Fourmy D, Guilloteau P. Differential tissular expression of the CCK(A) and CCK(B) gastrin receptor genes during postnatal development in the calf. Life Sci 1998. 63:2059-2070.
Lazennec G, Kern L, Valotaire Y, Salbert G. The nuclear orphan receptors COUP-TF and ARP-1 positively regulate the trout estrogen receptor gene through enhancing autoregulation. Mol Cell Biol 1997. 17:5053-5066.
Gestin M, Le Huerou-Luron I, Peiniau J, Thioulouse E, Desbois C, Le Drean G, Feldman D, Aumaitre A, Guilloteau P. Method of measurement of pancreatic elastase II activity and postnatal development of proteases in human duodenal juice and bovine and porcine pancreatic tissue. Dig Dis Sci 1997. 42:1302-1311.
Lazennec G, Kern L, Salbert G, Saligaut D, Valotaire Y. Cooperation between the human estrogen receptor (ER) and MCF-7 cell-specific transcription factors elicits high activity of an estrogen-inducible enhancer from the trout ER gene promoter. Mol Endocrinol 1996. 10:1116-1126.
Demay F, Geffroy S, Tiffoche C, de Monti M, Thieulant ML. Cell-specific mechanisms of estrogen receptor in the pituitary gland. Cell Biol Toxicol 1996. 12:317-324. Review.
Demay F, Tiffoche C, Thieulant ML. Effect of gonadotropin-releasing hormone on estrogen receptor messenger ribonucleic acid level in perifused pituitary cells. Cell Mol Neurobiol 1996. 16:397-402.
Demay F, Tiffoche C, Thieulant ML. Sex- and cell-specific expression of an estrogen receptor isoform in the pituitary gland. Neuroendocrinology 1996. 63:522-529.
Lu XP, Salbert G, Pfahl M. An evolutionary conserved COUP-TF binding element in a neural-specific gene and COUP-TF expression patterns support a major role for COUP-TF in neural development. Mol Endocrinol 1994. 8:1774-1788.
Apfel R, Benbrook D, Lernhardt E, Ortiz MA, Salbert G, Pfahl M. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol Cell Biol 1994. 14:7025-7035.
Anglade I, Pakdel F, Bailhache T, Petit F, Salbert G, Jego P, Valotaire Y, Kah O. Distribution of estrogen receptor-immunoreactive cells in the brain of the rainbow trout (Oncorhynchus mykiss). J Neuroendocrinol 1994. 6:573-583.
Zhang XK, Salbert G, Lee MO, Pfahl M. Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor. Mol Cell Biol 1994. 14:4311-4323.
Salbert G, Atteke C, Bonnec G, Jego P. Differential regulation of the estrogen receptor mRNA by estradiol in the trout hypothalamus and pituitary. Mol Cell Endocrinol 1993. 96:177-182.
Salbert G, Fanjul A, Piedrafita FJ, Lu XP, Kim SJ, Tran P, Pfahl M. Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity. Mol Endocrinol 1993. 7:1347-1356.
Flouriot G, Vaillant C, Salbert G, Pelissero C, Guiraud JM, Valotaire Y. Monolayer and aggregate cultures of rainbow trout hepatocytes: long-term and stable liver-specific expression in aggregates. J Cell Sci 1993. 105:407-416.
Chauveau I, Salbert G, Tranchand Bunel D, Vaudry H, Valotaire Y, Jego P. Cloning and sequencing of two POMC cDNAs in rainbow trout (Oncorhynchus mykiss). Effect of sex steroids on the expression of the POMC genes. Ann N Y Acad Sci 1993. 680:476-477.
Le Goff P, Salbert G, Prunet P, Saligaut C, Bjornsson BT, Haux C, Valotaire Y. Absence of direct regulation of prolactin cells by estradiol-17 beta in rainbow trout (Oncorhynchus mykiss). Mol Cell Endocrinol 1992. . 90:133-139.
Saligaut C, Garnier DH, Bennani S, Salbert G, Bailhache T, Jego P. Effects of estradiol on brain aminergic turnover of the female rainbow trout (Oncorhynchus mykiss) at the beginning of vitellogenesis. Gen Comp Endocrinol 1992. 88:209-216.
Salbert G, Chauveau I, Bonnec G, Valotaire Y, Jego P. One of the two trout proopiomelanocortin messenger RNAs potentially encodes new peptides. Mol Endocrinol 1992. 6:1605-1613.
Tran P, Zhang XK, Salbert G, Hermann T, Lehmann JM, Pfahl M. COUP orphan receptors are negative regulators of retinoic acid response pathways. Mol Cell Biol 1992. 12:4666-4676.
Saligaut C, Salbert G, Bailhache T, Bennani S, Jego P. Serotonin and dopamine turnover in the female rainbow trout (Oncorhynchus mykiss) brain and pituitary: changes during the annual reproductive cycle. Gen Comp Endocrinol 1992. 85:261-268.
Salbert G, Bonnec G, Le Goff P, Boujard D, Valotaire Y, Jego P. Localization of the estradiol receptor mRNA in the forebrain of the rainbow trout. Mol Cell Endocrinol 1991. 76:173-180.
Salbert G, Bailhache T, Zohar Y, Breton B, Jego P. A rapid and sensitive ELISA for rainbow trout maturational gonadotropin (tGtH II): validation on biological samples; in vivo and in vitro responses to GnRH. Gen Comp Endocrinol 1990. 78:110-122.