31. Métivier R, Gallais R, Tiffoche C, Le Péron C, Jurkowska R, Carmouche RP, Ibberson D, Barath P, Demay F, Reid G, Benes V, Jeltsch A, Gannon F, Salbert G. Cyclical DNA methylation of a transcriptionally active promoter. Submitted

30. Kangaspeska S, Stride B, Métivier R, Ibberson D, Carmouche RP, Benes V, Gannon F, Reid G. Transient, cyclical methylation of genes. Submitted

29. Huet G, Mérot Y, Le Dily F, Kern L, Ferrière F, Saligaut C, Boujrad N, Pakdel F, Métivier R, Flouriot G. Loss of E-cadherin-mediated cell contacts reduces estrogen receptor alpha (ERα) transcriptional efficiency by affecting the respective contribution exerted by AF1 and AF2 transactivation functions. BBRC. In Press.

28. Nettles KW, Gil G, Nowak J, Métivier R, Sharma VB, Greene GL. CBP is a dosage dependent regulator of NFκB suppression by the estrogen receptor. Mol Endocrinol 2007 [Epub ahead of print]

27. Feige JN, Gelman L, Rossi D, Zoete V, Métivier R, Tudor C, Anghel SI, Grosdidier A, Lathion C, Engelborghs Y, Michielin O, Wahli W, Desvergne B. Mono-ethyl-hexyl-phthalate is an endocrine disruptor acting as a selective modulator of PPARγ activity. J Biol Chem 2007 282:19152-19166

26. Gallais R, Demay F, Barath P, Finot L, Jurkowska R, Le Guevel R, Gay F, Jeltsch A, Métivier R, Salbert G. Deoxyribonucleic Acid Methyl Transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene Activation. Mol Endocrinol 2007 21:2085-2098

25. Le Dily F, Métivier R, Gueguen MM, Le Péron C, Flouriot G, Tas P, Pakdel F. COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells. Breast Cancer Res Treat 2007 [Epub ahead of print]

24. Lemaire V, Lee CF, Lei J, Métivier R, Glass L. Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation. Phys Rev Lett 2006 96:198102

23. Métivier R, Reid G, Gannon F. Transcription in four dimensions: nuclear receptor-directed initiation of gene expression. EMBO Rep 2006 7:161-167

22. Valley CC, Métivier R, Solodin NM, Fowler AM, Mashek MT, Hill L, Alarid ET. Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor N-terminus Mol Cell Biol 2005 25:5417-5428.

21. Reid G, Métivier R, Lin CY, Denger S, Ibberson D, Ivacevic T, Brand H, Benes V, Liu ET, Gannon F. Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor alpha, in response to deacetylase inhibition by valproic acid and trichostatin A. Oncogene 2005 24:4894-4907

20. Penot G, Le Péron C, Merot Y, Grimmaud-Fanouillère E, Ferrière F, Boujrad N, Kah O, Saligaut C, Ducouret B, Métivier R, Flouriot G. The human estrogen receptor alpha isoform hERα46 antagonizes the proliferative influence of hERα66 in MCF7 breast cancer cells. Endocrinology 2005 146:5474-5484

19. Métivier R. Activation of gene transcription. Med Sci Paris 2004 20:391-393

18. Métivier R, Penot G, Carmouche RP, Hübner MR, Reid G, Denger S, Manu D, Brand H, Kos M, Benes V, Gannon F. Transcriptional complexes engaged by apo-estrogen receptor-α isoforms have divergent outcomes. EMBO J 2004 23:3653-3666.

17. Merot Y, Métivier R, Penot G, Manu D, Saligaut C, Gannon F, Pakdel F, Kah O, Flouriot G. The relative contribution that both AF-1 and AF-2 transactivation functions exert on estrogen receptor alpha (ERα) transcriptional activity is cell differentiation stage dependent. J Biol Chem 2004 279: 26184-26191

16. Bourdeau V, Deschênes J, Métivier R, Nagai Y, Nguyen D, Bretschneider N, Gannon F, White JH, Mader S. Genome-wide identification of high affinity estrogen response elements in human and mouse. Mol Endocrinol 2004 18:1411-1427

15. Métivier R, Penot G, Hübner MR, Reid G, Brand H, Kos M, Gannon F. Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 2003 115:751-763

14. Reid G, Hübner MR, Métivier R, Brand H, Denger S, Manu D, Beaudouin J, Ellenberg J, Gannon F. Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signalling. Mol Cell 2003 11:695-707

13. Métivier R, Stark A, Flouriot G, Hübner MR, Brand H, Penot G, Manu D, Denger S, Reid G, Koš M, Russell RB, Kah O, Pakdel F, Gannon F. A dynamic structural model for estrogen receptor-alpha activation by ligands emphasizing the role of interactions between distant A and E domains. Mol Cell 2002 10:1019-1032

12. Métivier R, Gay F, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F. Formation of an hER?-COUP-TFI complex enhances hER? AF-1 through Ser118 phosphorylation by MAPK. EMBO J 2002 21:3443-3453

11. Gay F, Barath P, Desbois C, Métivier R, Le Guével R, Birse D, Salbert G. Multiple phosphorylation events control COUP-TFI orphan receptor activity. Mol Endocrinol 2002 16:1332-1351

10. Métivier R, Gay F, Hübner MR, Flouriot G, Salbert G, Kah O, Pakdel F. Enhancement of estrogen receptor α (ERα) activation function-1 by physical association with the orphan nuclear receptor COUP-TFI involves ERα phosphorylation by MAPKinases. Biol Cell 2001 93:103

9. Métivier R, Penot G, Flouriot G, Pakdel F. Synergism between ERα transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 α-helical core and for a direct interaction between the N- and C-terminal domains. Mol Endocrinol 2001 15:1953-1970

8. Le Guevel R, Petit F, Le Goff P, Métivier R, Valotaire Y, Pakdel F. Cadmium: an inhibitor of estrogen receptor activity. Biol Reprod 2000 63:259-266

7. Adam F, Sourisseau T, Métivier R, Le Page Y, Desbois C, Michel D, Salbert G. COUP-TFI regulates cell migration and axogenesis in differentiating P19 embryonal carcinoma cells. Mol Endocrinol 2000 14:1918-1933

6. Métivier R, Petit FG, Valotaire Y, Pakdel F. Function of N-terminal transactivation domain of estrogen receptor requires a potential α -helical structure and is negatively regulated by the A domain. Mol Endocrinol 2000 14:1849-1871

5. Flouriot G, Brand H, Denger S, Métivier R, Kos M, Reid G, Sonntag-Buck V, Gannon F. Identification of a new isoform of the human estrogen receptor-alpha (hER-α) that is encoded by distinct transcripts and that is able to repress hER-α activation function 1. EMBO J 2000 19:4688-4700

4. Métivier R, Le Dréan Y, Salbert G, Pakdel F. Interplay between liganded and orphan nuclear receptors controls reproductive pathways. Biochem Cell Biol 2000 78:345-358

3. Pakdel F, Métivier R, Flouriot G, Valotaire Y. Two estrogen receptor (ER) isoforms with different estrogen-dependencies are generated from the trout ER gene. Endocrinology 2000 141:571-580

2. Petit FG, Métivier R, Valotaire Y, Pakdel F. Synergism between a half-site and an imperfect estrogen-responsive element, and cooperation with COUP-TFI are required for estrogen receptor (ER) to achieve a maximal estrogen-stimulation of rainbow trout ER gene. Eur J Biochem 1999 259:385-395

1. Métivier R, Petit F, Valotaire Y, Pakdel F. Reconstitution of a complex transcriptional unit from the rainbow trout estrogen receptor gene in yeast Saccharomyces cerevisiæ. Bull Fr Pêche Piscic 1998 350-351:609-621

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